Current Issue : April-June Volume : 2020 Issue Number : 2 Articles : 2 Articles
In this present work, fast dissolving tablets of charantin were prepared by direct compression method to minimize bitter taste and to reduce first pass hepatic metabolism. Three superdisintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios (5% and 10%) along with beta cyclodextrin, microcrystalline cellulose, Saccharin sodium were used. Saccharin sodium used as effective taste masking agent. The various precompression parameters were determined for the powder blend and the prepared batches of tablets were evaluated for hardness, friability, weight variation, wetting time, water absorption ratio, in-vitro disintegration time and in-vitro dissolution time. IR studies indicates that no interaction between drug and excipients. Short term stability studies on the formulations also indicates that no physical or chemical changes in the formulations during the study period....
Topical drug delivery is one of the sought after routes of drug delivery for the numerous advantages it offers. The potential of several novel drug delivery carriers for topical delivery has been established through decades of research. Fullerene, an allotrope of carbon, is a bulky molecule with 60 carbon atoms. This distinctive class of polyhedral carbon structure has been studied extensively for its distinctive material properties and potential technological applications. Fullerene’s unique carbon cage structure has tremendous scope for derivatization which makes them potential therapeutic agents. This paper discusses medically relevant applications of fullerenes, with main focus on their dermatological use....
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